Costimulation in antiviral immunity: differential requirements for CD4+ and CD8+ T cell responses
Identifieur interne : 001918 ( Main/Exploration ); précédent : 001917; suivant : 001919Costimulation in antiviral immunity: differential requirements for CD4+ and CD8+ T cell responses
Auteurs : Jason K. Whitmire [États-Unis] ; Rafi Ahmed [États-Unis]Source :
- Current Opinion in Immunology [ 0952-7915 ] ; 2000.
English descriptors
- Teeft :
- Adenovirus, Agonistic, Agonistic antibody, Ahmed, Antiviral, Antiviral immunity whitmire, Apc, Cell, Cell activation, Cell number, Cell proliferation, Cell response, Cell responses, Costimulation, Costimulatory, Costimulatory interactions, Costimulatory molecules, Costimulatory signals, Ctls, Current opinion, Cytotoxic, Death phase, Flavell, Grewal, Immune, Immune response, Immunol, Immunology, Infection, Influenza, Influenza virus, Influenza virus infection, Intracellular staining, Lcmv, Ligand, Lymphocyte, Macrophage, Memory cells, Mouse, Pathway, Receptor, Tnfr superfamily, Vaccinia, Vaccinia virus, Viral, Viral infection, Virol, Whitmire.
Abstract
Abstract: A key step toward improving vaccines is understanding the molecular interactions responsible for inducing antiviral T cell responses. An emerging theme from recent studies is that CD4+ and CD8+ T cell responses require distinct costimulatory pathways for activation. In addition, these costimulatory interactions can play a crucial role during the death phase of the T cell response and determine the number of effector T cells that survive to become memory T cells.
Url:
DOI: 10.1016/S0952-7915(00)00119-9
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Abstract: A key step toward improving vaccines is understanding the molecular interactions responsible for inducing antiviral T cell responses. An emerging theme from recent studies is that CD4+ and CD8+ T cell responses require distinct costimulatory pathways for activation. In addition, these costimulatory interactions can play a crucial role during the death phase of the T cell response and determine the number of effector T cells that survive to become memory T cells.</div>
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